Bills lose QB, 1st game

Cardinals 41, Bills 17

GLENDALE, Ariz. -- The Bills lost their quarterback and, emphatically, their first game of the season.

Second-year quarterback Trent Edwards, a major reason Buffalo was one of three unbeaten teams entering the day, went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game. It was the Bills' defense that collapsed after that.

Rookie Tim Hightower had a pair of touchdown runs and Kurt Warner threw to Larry Fitzgerald twice for scores. Warner, who committed six of Arizona's seven turnovers in last week's loss at the Jets, bounced back to go 33-of-42 for 250 yards with no interceptions. The Cardinals (3-2) are 3-0 at home.

Without standout receiver Anquan Boldin (head injury), Arizona amassed 373 yards against what had been one of the stingier defenses in the league. Buffalo's offense contributed, too, fumbling three times in Bills territory, resulting in 17 Arizona points.

J.P. Losman, who wanted an offseason trade after losing his job to Edwards, was 15-of-21 for 220 yards, most of them on an 87-yard touchdown pass to Lee Evans.

Colts 31, Texans 27

HOUSTON -- Peyton Manning turned a colossal collapse by the Houston Texans into a stunning victory for the Indianapolis Colts.

The Colts scored 21 points in a late span of 2:10 -- two touchdowns thanks to fumbles by Sage Rosenfels -- then intercepted Rosenfels' last-ditch comeback attempt for a 31-27 win Sunday.

Manning threw two touchdown passes, connecting with Reggie Wayne on a 5-yarder with 1:54 remaining for the decisive points. Linebacker Gary Brackett returned a fumble by quarterback Rosenfels 68 yards for a score in between Manning's TD throws.

Rookie Tom Santi caught the other late score, a 7-yarder to bring the Colts (2-2) within 27-17 with 4:04 to go. It was his first NFL touchdown.

Backup Rosenfels, playing for the ill Matt Schaub, had the winless Texans (0-4) ahead by 17 points before losing two fumbles and throwing an interception. Texans fans had wanted to see Schaub replaced all season, and Rosenfels was nearly flawless for three quarters. Then came one of the most worst collapses in the history of the young franchise.

After Manning found Santi for his touchdown, Indianapolis attempted an onside kick, but Houston recovered. On the next drive, Rosenfels ran right at defensive back Marlin Jackson, who upended him and knocked the ball loose. Brackett ran it in to make it 27-24.

On the ensuing drive, Robert Mathis sacked Rosenfels and stripped the ball at the Houston 19. Manning hit a leaping Wayne in the corner of the end zone, the play was reviewed, and the call was upheld.

The Texans played the 100th game in franchise history in their hurricane-damaged stadium with the retractable roof open; the roof couldn't be repaired in time for Sunday's game. Houston was supposed to host Baltimore in Week 2 when Hurricane Ike hit, but that game was postponed until Nov. 9.

Steelers 26, Jaguars 21

JACKSONVILLE, Fla. -- Big Ben's big night gave the Pittsburgh Steelers a big boost in the AFC North.

Ben Roethlisberger threw for 309 yards and three touchdowns, helping the Steelers (4-1) overcome their offensive woes and snap a four-game losing streak against Jacksonville (2-3).

Roethlisberger finished 26-of-41, rebounding from an interception on his third pass that Rashean Mathis returned 72 yards for a score. Roethlisberger's perfect 8-yard fade pass to Hines Ward in the corner of the end zone put the Steelers ahead 26-21 with 1:53 remaining.

Roethlisberger misfired on the 2-point conversion, but Pittsburgh's defense sealed the win by sacking David Garrard and then forcing two incomplete passes.

The Jaguars blew a late lead for the fourth consecutive week.