Carlos Quentin homered and drove in three runs and the San Diego Padres battered Cubs starter Edwin Jackson in a 13-7 win over Chicago on Tuesday night.
Edinson Volquez (2-3) was good enough to beat the Cubs for the fifth time in his career, working 5 2-3 innings and allowing four runs while striking out three in his first outing against Chicago while with San Diego. Volquez is 5-0 in seven career starts against the Cubs, including 3-0 at Wrigley Field.
Quentin was 3 for 4 with the home run and two doubles. He is 34 for 101 (. 337) with nine homers against the Cubs in his career.
Jackson (0-4) is still seeking his first win since signing a four-year, $52 million contract in the offseason. He pitched 4 2-3 innings, giving up 11 hits and eight runs, and was booed off the field when he was removed by Cubs manager Dale Sveum.
San Diego, which had a four-game winning streak snapped Monday, has won five of its last six games. The Padres' run total -- the most they've ever scored at Wrigley -- and their 17 hits were both season highs.
Yonder Alonso and Nick Hundley both had three hits and a home run for San Diego.
The Padres broke the game open with five runs in the fifth, all charged to Jackson, to take an 8-0 lead. Alonso's two-run homer gave the Padres a 7-0 lead, while Chase Headley and Quentin had RBI doubles in the inning.
Volquez's sharp single to center capped San Diego's scoring in the inning.
The win is Volquez's second straight after the right-hander beat Milwaukee on April 24 with seven shutout innings. His walk of Dave Sappelt to lead off the sixth ended a streak of 13 consecutive innings without allowing a base on balls.
He also walked Luis Valbuena and Darwin Barney with two outs to load the bases and end his night at 96 pitches. Dale Thayer then replaced Volquez, and ended the inning by getting Julio Borbon to fly out to right.
The Cubs' streak of 25 games decided by four runs or fewer to start their season was snapped. The 25 games was a team record and second all-time behind only the 1914 Tigers (33 games).
Chicago tried to mount a comeback in the fifth. Valbuena and Starlin Castro both had two-run home runs, cutting San Diego's lead in half. With one out in the inning, a Borbon line drive hit Volquez in the left foot. Volquez made the play to get Borbon at first and stayed in the game.
Quentin's second home run of the season in the sixth gave San Diego a 9-4 lead.
David DeJesus' home run in the seventh that cut the Padres' lead to 10-5 was originally called a double but was overturned after a review.
Hundley's three-run home run in the eighth gave the Padres a 13-5 lead.
Cody Ransom homered in the ninth for the Cubs, giving him home runs in consecutive games against his former team. Anthony Rizzo was 3 for 4 with two doubles and an RBI.
NOTES: Mark Kotsay was in right field for the Padres, his first start since April 22 against Milwaukee. Before Tuesday, Kotsay had two at-bats in San Diego's last six games, both strikeouts. Chris Denorfia moved to center. . Wednesday's pitching matchup is San Diego's Andrew Cashner (1-1, 3.26 ERA) against the Cubs' Scott Feldman (1-3, 2.92). Cashner was a first-round pick by the Cubs in 2008 and was traded to San Diego for Rizzo in January 2012. . Sveum said he's got a closer but he "doesn't know who it's going to be every night." ... Cubs reliever Kyuji Fujikawa is scheduled to have a bullpen session Thursday, and if that goes well he will begin a rehab assignment Sunday at Triple-A Iowa. Fujikawa has been on the disabled list since April 13 with a right forearm strain.