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No. 6 LSU opens title defense vs. Mississippi State

Mississippi State at No. 6 LSU, Saturday at 3:30 ET (CBS).

Line: LSU by 16 1/2.

Series record: LSU leads 75-35-3.

WHAT'S AT STAKE?

Defending national champion LSU seeks to justify the top 10 ranking it received despite seeing 14 of last season's players selected in the 2020 NFL draft, tying a record for a seven-round draft set by Ohio State in 2004. Mississippi State seeks to open the era of new coach Mike Leach with a statement victory in Tiger Stadium.

KEY MATCHUP

LSU's revamped defensive roster '“ and scheme '“ under new coordinator Bo Pelini vs. the Bulldogs' new offensive scheme under Leach, who is preceded by his reputation as an architect of potent spread offenses.

PLAYERS TO WATCH

Mississippi State: RB Kylin Hill returns for his senior campaign after rushing for 1,350 yards and 10 touchdowns last season.

LSU: QB Myles Brennan, once a coveted recruit from Mississippi, makes his LSU debut as starter following three years in a reserve role, first under Danny Etling in 2017 and then graduate transfer Joe Burrow, the 2019 Heisman Trophy winner, the past two seasons.

FACTS & FIGURES

Mississippi State's last victory in Baton Rouge came when Dak Prescott was the Bulldogs' QB in 2014. ... Mississippi State has won just twice in Tiger Stadium since 1991. ... Like LSU, Mississippi State also has a new defensive coordinator after Leach hired Zach Arnett away from San Diego State. ... The Tigers have won two straight in the series, four of the past six and 18 of the last 20. ... LSU has not lost since its final regular season game of 2018, having won 16 straight since, starting with the Fiesta Bowl that season and running through last season's College Football Playoff. That's the longest active winning streak in the nation. ... LSU's record for consecutive victories is 19 between 1957 and 1959.

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FILE - LSU defensive end Neil Farrell Jr. (92) sacks Georgia Southern quarterback Justin Tomlin (17) in the fourth quarter during an NCAA college football game in Baton Rouge, La., Saturday, Aug. 31, 2019. LSU coach Ed Orgeron says defensive lineman Neil Farrell has rejoined the team after initially opting out more than a month ago. But the 6-foot-4 and 319-pound Farrell's readiness for the season opener against Mississippi State on Sept. 26 remains to be seen. (AP Photo/Michael Democke, File) The Associated Press
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