Second Amendment isn't any different
Both guns and cars injure and kill, both intentionally and accidentally. Americans accept that cars must have recorded titles, that transfers of titles are recorded, that skill in driving a car and knowing the Rules of the Road must be periodically tested, that annual state and local registration/sticker fees are allowed, that liability insurance coverage is mandated, etc.
I see no reason why guns should not be similarly regulated. All our constitutionally granted freedoms (religion, speech, etc.) come with limitations.
Why is the Second Amendment (right to bear arms) any different?
Mary F. Warren