INDIANAPOLIS (AP) -- Andrew Luck threw for three touchdowns and ran for another Sunday night, outplaying predecessor Peyton Manning in a 39-33 victory over the previously unbeaten Denver Broncos.
The victory ended the Broncos' 17-game regular-season winning streak in the first game Manning played against his former team since being released in March 2012.
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Manning finished 29 of 49 for 386 yards with three TDs and one interception. He was sacked four times and tried desperately to rally the Broncos (6-1) late.
But the Colts (5-2) took advantage of his and Denver's uncharacteristic mistakes.
Luck converted an early fumble into a TD pass. Indy got nine points out of a second-quarter strip sack, and Luck scored on a 10-yard run in the third quarter, a drive helped by a series of defensive penalties. When the Broncos finally had a chance to tie it, Manning was intercepted.
Indianapolis has not lost consecutive games under Luck.