OAKLAND, Calif. -- Hector Santiago walked Josh Reddick with the bases loaded and two outs in the 10th inning to force in the winning run and lift the Oakland Athletics over the Chicago White Sox 4-3 on Saturday.
The A's had 16 hits and failed to score after loading the bases with no outs in the ninth before scoring the game-winner off Santiago (1-4).
Chris Young, who had two hits, started the rally with a one-out double. After Yoenis Cespedes was intentionally walked, Josh Donaldson drew a free pass from Santiago to load the bases. Brandon Moss then lined out to second before Reddick walked on five pitches.
Jed Lowrie matched his career high of four hits for the A's, who have won seven straight at home and 13 of 15 overall.
Jerry Blevins (4-0) retired one batter to get the win after Oakland manager Bob Melvin emptied his bullpen following a stellar effort by starter Dan Straily.
Straily struck out eight in six innings and left with a 3-1 lead before Chicago scored two runs in the seventh to tie it.
Alejandro De Aza had two hits and two RBIs for the White Sox, who have lost five straight.
Reddick, who came off the disabled list on Friday, had two hits before drawing the first game-ending walk of his career.
Cespedes doubled in Lowrie in the first, then Young snapped an 0-for-19 streak with an RBI single in the second to put the A's up 2-0.
After De Aza doubled and scored on Adam Dunn's single in the third, Oakland made it 3-1 when Donaldson hit a one-out single and scored on Nate Freiman's triple in the fifth. It came after Chicago starter Jose Quintana was called for a balk when he stumbled off the mound and dropped the ball during his windup.
Quintana left after giving up a one-out double to Lowrie in the sixth. The left-hander walked three and struck out four.
The White Sox, shut out a day earlier by 40-year-old Bartolo Colon, couldn't get much going against Straily but broke through against the A's bullpen in the seventh.
Jeff Keppinger singled off reliever Sean Doolittle and took third on Hector Gimenez's double. De Aza followed with a sharp two-run single to drive in both runs and tie the game at 3-all.
Donaldson reached on an infield single leading off the ninth against Nate Jones. Santiago relieved Jones and walked Moss, then gave up a bunt single to Reddick. Santiago got Derek Norris to ground into a 6-2-3 double play, then later fanned Eric Sogard to end the jam.
It was a rough day all around for the slumping White Sox.
Designated hitter Paul Konerko struck out twice before leaving the game with a stiff neck. Shortstop Alexei Ramirez also appeared to injure his lower back after bumping into left fielder Dayan Viciedo chasing down a popup by Cespedes also in the sixth but stayed in the game.
NOTES: Quintana, who tied for second in the AL with 15 no-decisions in 2012, already has six this season. ... Chicago LHP Chris Sale (5-2) takes a 23-inning scoreless streak into Sunday's series finale. ... Oakland RHP Jarrod Parker (3-6) will make just his second career start against the White Sox. ...