Russ Smith scored 17 points, Peyton Siva had 16 and No. 10 Louisville beat DePaul 79-58 on Wednesday night for its fourth consecutive victory.
Chane Behanan added 10 points and nine rebounds for the Cardinals (23-5, 11-4 Big East), who held the Blue Demons to 36 percent shooting and forced 19 turnovers. Smith also had five assists and four steals.
Louisville is unbeaten since it lost 104-101 in five overtimes at Notre Dame on Feb. 9 in the longest regular-season game in Big East history. With the victory over sliding DePaul, the Cardinals moved into a tie with Marquette for second place in the conference behind Georgetown.
Rick Pitino's team visits No. 12 Syracuse, and Notre Dame takes on Marquette in a big slate of games for the Big East on Saturday.
Brandon Young scored 22 points and Cleveland Melvin had 20 for the Blue Demons (11-17, 2-13), who have dropped three in a row and 12 of 13 overall.