Return specialist Devin Hester and guard Chris Spencer have been ruled out for Sunday's game against Seattle.
Both players were injured in a win over Minnesota last weekend. Hester had a concussion and Spencer has a knee injury.
The Bears were a banged up bunch after playing the Vikings, with running back Matt Forte, cornerback Charles Tillman and linebacker Lance Briggs suffering ankle injuries and guard Lance Louis tearing the anterior cruciate ligament in his left knee.
Briggs, Forte, Tillman and tight end Kellen Davis (ankle) all were limited in practice on Thursday. Louis is out for the rest of the season.