NEW YORK -- First, Darrelle Revis. Now, Santonio Holmes.
A person familiar with the situation told The Associated Press on Tuesday night that Holmes has a Lisfranc injury in his left foot, likely leaving the New York Jets' struggling offense without its top playmaker for the rest of the season.
That news comes just over a week after the team lost Revis, considered by many to be the NFL's best cornerback, for what will likely be the season with a torn ligament in his left knee.
Holmes went down on the first play of the fourth quarter of the Jets' 34-0 loss to the San Francisco 49ers on Sunday after catching a short pass and tossing the ball as he went down, with Carlos Rogers returning the fumble 51 yards for a touchdown.
X-rays on the foot were negative, but subsequent MRI exam results were sent to a foot specialist in North Carolina for further evaluation.
The Jets' fears were then confirmed, according to the person who spoke on condition of anonymity because the team had not announced the severity of the injury.
Yahoo Sports first reported the nature of Holmes' injury.
The Jets said earlier Tuesday night that the team would have no further update on Holmes.
It's another big blow for New York, which is going through a rough stretch that includes losing two of their best players and coming off the embarrassing defeat to San Francisco with a home game Monday night up next against the undefeated Houston Texans.
Meanwhile, quarterback Mark Sanchez is taking lots of criticism for his shoddy play, with many calling for Tim Tebow to see more action on offense -- and possibly move into the starting role.
Either way, it appears Holmes won't be around to catch passes again this season. It wasn't immediately known if Holmes' foot is fractured, but a Lisfranc injury usually involves the tearing of the ligament that holds the first two toes in the foot together.
Recovery time depends on whether there is a dislocation or fracture, and whether surgery -- including screws inserted -- is needed.
Oakland wide receiver Jacoby Ford is out for the year with a similar injury, while Houston quarterback Matt Schaub and Raiders running back Darren McFadden are back after missing time last season with Lisfranc injuries.