Kevin Youkilis hit a grand slam, Paul Konerko homered and Dewayne Wise had four hits Tuesday night as the White Sox rallied for the second straight game to beat the New York Yankees 7-3.
The Sox, which fell behind 3-0 in Monday night's opener before winning 9-6, trailed 2-0 after one inning Tuesday in the matchup of division leaders.
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Wise, designated for assignment by the Yankees in July, had four singles from the leadoff spot and has played well while filling in for the injured Alejandro De Aza.
It was Youkilis' second grand slam this season at U.S. Cellular Field. He also cleared the bases in April for Boston against the White Sox and Phil Humber.
Since joining the White Sox in a June trade with the Red Sox, Youkilis has hit 11 of his 15 homers.