New study shows chronic fatigue isn't just in your head. It may have to do with your gut.

Scientists have finally shed some light on chronic fatigue syndrome, finding that your gut bacteria and inflammatory agents in the blood may have something to do with it.

In a study published recently in the journal Microbiome, Cornell University researchers looked at stool and blood samples of 48 people diagnosed with chronic fatigue syndrome (or more formally, myalgic encephalomyelitis) and at 39 healthy volunteers.

They found two main differences: through DNA sequencing, they found the stool samples in the patients with the condition had less diversity in bacteria present in the gut and that there were fewer that were anti-inflammatory.

The blood samples were also distinct: There were markers of inflammation that the researchers theorized may be due to a "leaky gut from intestinal problems that allow bacteria to enter the blood."

The researchers said that it was unclear whether these were causes or a consequences of the disease, but the discovery, despite the fact that it was only based on a small sample, is important for two reasons.

First, the indicators could be used in the future to help diagnose the condition, as they were present in 83 percent of the patients with chronic fatigue syndrome. Second, it suggests that diet and things like probiotics may be a way to help treat the disease by getting the gut microbiome back in balance.

"Our work demonstrates that the gut bacterial microbiome in chronic fatigue syndrome patients isn't normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease," said Maureen Hanson, a professor of molecular biology and genetics at Cornell.

"Furthermore, our detection of a biological abnormality provides further evidence against the ridiculous concept that the disease is psychological in origin."