Adam Dunn hit a one-out home run in the bottom of the ninth inning off Tommy Hunter to give the White Sox a 3-2 victory over the Baltimore Orioles on Thursday at U.S. Cellular Field.
Sox starter Jose Quintana had a career-high 11 strikeouts and reliever Addison Reed (2-0) got the victory.
Dunn homered to left off Hunter (3-2) to end the game.
Quintana went a seventh straight game without a decision, allowing two hits over seven innings. He retired the last 13 Orioles he faced.
Alex Rios broke up a scoreless tie in the sixth inning with an RBI single and Dunn followed with an RBI single off Zach Britton.
Baltimore scored twice in the eighth off reliever Nate Jones, one on an RBI infield grounder by pinch-hitter Matt Wieters and the other on Nick Markakis' sacrifice fly.
Quintana's previous career high for strikeouts had been eight on July 5, 2012 against Texas.
Baltimore starter Zach Britton struck out three, walked one and gave up six hits over seven innings in his longest stint of the season.
Rios, who went 2 for 3, singled up the middle off Britton for the game's first run after Alexei Ramirez had led off with a double down the left-field line. After Ramirez scored on Rios' hit and Dayan Viciedo flew out, Dunn singled up the middle for a 2-0 Chicago lead.