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When Jay Mesinger heard about a study seeking golden retrievers to help fight canine cancer, he immediately signed up 2-year-old Louie. He and his wife know firsthand the toll of canine cancer: Louie is their fourth golden retriever. The first three died of cancer. For Louie and 2,999 other purebred goldens, it will be the study of a lifetime. Their lives — usually a 10- to 14-year span — will be tracked for genetic, nutritional and environmental risks to help scientists and veterinarians find ways to prevent canine cancer.